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Retrograde ejaculation is another condition that causes male infertility. This is when semen is wrongly directed back into the bladder as opposed to out of the body through the urethra. Retrograde ejaculation can be a result of diabetes, intake of medication (such as drugs used to treat high blood pressure), injury or past surgeries. Little or no semen released during ejaculation, or the presence of cloudy urine after intercourse, are symptoms of retrograde ejaculation.

During treatment, sperm can be recovered from a urine sample and used during an In-Vitro Fertilisation (IVF)/Intra-Cytoplasmic Sperm Injection (ICSI) cycle. Alternatively, sperm can be retrieved through a surgical sperm retrieval or SSR procedure such as Testicular Sperm Aspiration or TESA.