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Secondary infertility refers to a condition when a couple who has already naturally conceived a child, face difficulties while trying to become pregnant again. Invariably, when a childless couple is unable to conceive, they tend to seek advice or treatment. This does not hold true always with couples who have secondary infertility, as they feel there is no cause for concern, having already had a child through natural conception.

Several lifestyle-related factors such as smoking, drinking, and obesity; injuries or diseases, which may have occurred since the last pregnancy, could impact fertility the second or third time around.